Living, breathing human lung-on-a-chip

Researchers at Harvard’s Wyss Institute for Biologically Inspired Engineering have created a device that mimics a living, breathing human lung on a microchip. The device, about the size of a rubber eraser, acts much like a lung in a human body and is made using human lung and blood vessel cells.Because the lung device is translucent, it provides a window into the inner-workings of the human lung without having to invade a living body. It has the potential to be a valuable tool for testing the effects of environmental toxins, absorption of aerosolized therapeutics and the safety and efficacy of new drugs. Such a tool may help accelerate pharmaceutical development by reducing the reliance on current models, in which testing a single substance can cost more than $2 million.“The ability of the lung-on-a-chip device to predict absorption of airborne nanoparticles and mimic the inflammatory response triggered by microbial pathogens, provides proof-of-principle for the concept that organs-on-chips could replace many animal studies in the future,” says Donald Ingber, senior author on the study and founding director of Harvard’s Wyss Institute.Click here to watch an interview with Donald Ingber.The work is being published in tomorrow’s edition of Science.Room to breatheUntil now, tissue-engineered microsystems have been limited either mechanically or biologically, says Ingber, the Judah Folkman professor of vascular biology at Harvard Medical School (HMS) and Children’s Hospital Boston. “We really can’t understand how biology works unless we put it in the physical context of real living cells, tissues and organs.”With every human breath, air enters the lungs, fills microscopic air sacs called alveoli and transfers oxygen through a thin, flexible, permeable membrane of lung cells into the bloodstream. It is this membrane—a three-layered interface of lung cells, a permeable extracellular matrix and capillary blood vessel cells—that does the lung’s heavy lifting. What’s more, this lung-blood interface recognizes invaders such as inhaled bacteria or toxins and activates an immune response.The lung-on-a-chip microdevice takes a new approach to tissue engineering by placing two layers of living tissues—the lining of the lung’s air sacs and the blood vessels that surround them—across a porous, flexible boundary. Air is delivered to the lung lining cells, a rich culture medium flows in the capillary channel to mimic blood and cyclic mechanical stretching mimics breathing.The device was created using a novel microfabrication strategy that uses clear rubbery materials. The strategy was pioneered by another Wyss core faculty member, George Whitesides, the Woodford L. and Ann A. Flowers University Professor at Harvard.“We were inspired by how breathing works in the human lung through the creation of a vacuum that is created when our chest expands, which sucks air into the lung and causes the air sac walls to stretch,” says first author Dan Huh, a Wyss technology development fellow at the Institute. “Our use of a vacuum to mimic this in our microengineered system was based on design principles from nature.”To determine how well the device replicates the natural responses of living lungs to stimuli, the researchers tested its response to inhaled living E. coli bacteria. They introduced bacteria into the air channel on the lung side of the device and at the same time flowed white blood cells through the channel on the blood vessel side. The lung cells detected the bacteria and, through the porous membrane, activated the blood vessel cells, which in turn triggered an immune response that ultimately caused the white blood cells to move to the air chamber and destroy the bacteria.“The ability to recreate realistically both the mechanical and biological sides of the in vivo coin is an exciting innovation,” says Rustem Ismagilov, professor of chemistry at the University of Chicago, who specializes in biochemical microfluidic systems.The team followed this experiment with a “real-world application of the device,” says Huh. They introduced a variety of nano-scaled particles (a nanometer is one-billionth of a meter) into the air sac channel. Some of these particles exist in commercial products; others are found in air and water pollution. Several types of these nanoparticles entered the lung cells and caused the cells to overproduce free radicals and to induce inflammation.Many of the particles passed through the model lung into the blood channel, and the investigators discovered that mechanical breathing greatly enhanced nanoparticle absorption. Benjamin Matthews, Harvard Medical School assistant professor in the Vascular Biology Program at Children’s Hospital, verified these new findings in mice.“Most importantly, we learned from this model that the act of breathing increases nanoparticle absorption and that it also plays an important role in inducing the toxicity of these nanoparticles,” Huh says.Organs-on-chips“This lung-on-a-chip is neat and merges a number of technologies in an innovative way,” says Robert Langer, MIT Institute professor. “I think it should be useful in testing the safety of different substances on the lung and I can also imagine other related applications, such as in research into how the lung functions.”According to Ismagilov, it’s too early to predict how successful this field of research will be.Still, “the potential to use human cells while recapitulating the complex mechanical features and chemical micro environments of an organ could provide a truly revolutionary paradigm shift in drug discovery,” he says.The investigators have not yet demonstrated the system’s capability to mimic gas exchange between the air sac and bloodstream, a key function of the lungs, but, says Huh, they are exploring this now.The Wyss Institute team is also working to build other organ models, such as a gut-on-a-chip, as well as bone marrow and even cancer models. Further, they are exploring the potential for combining organ systems.For example, Ingber is collaborating with Kevin Kit Parker, associate professor at Harvard’s School of Engineering and Applied Sciences and another Wyss core faculty member, who has created a beating heart-on-a-chip. They hope to link the breathing lung-on-a-chip to the beating heart-on-a-chip. The engineered organ combination could be used to test inhaled drugs and to identify new and more effective therapeutics that lack adverse cardiac side effects.This research was funded by the the National Institutes of Health, the American Heart Association and the Wyss Institute. read more

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Frost & Sullivan: Global renewable capacity to climb 155GW in 2018

first_imgFrost & Sullivan: Global renewable capacity to climb 155GW in 2018 FacebookTwitterLinkedInEmailPrint分享Renewables Now:Investments in renewable energy capacity globally will reach USD 228.3 billion (EUR 197bn) this year, up by just 0.7% on 2017 as China’s decision to limit solar capacity additions has hit year-on-year growth, Frost & Sullivan says.According to the company’s Global Renewable Energy Outlook, 2018, the world will install 154.6 GW of renewables in 2018, including 90 GW of solar photovoltaic (PV) parks and 53 GW of wind. Biomass, geothermal, and small hydropower are also growing, but their expansion is constrained by resource availability and the higher risks and upfront costs for such technologies.Asia will bring over half of 2018 global investment, or USD 114.96 billion. According to Frost & Sullivan, 96% of that will be investments in solar, wind and biomass. Asia will account for 58% of the global new installed capacity in 2018.Investment in North America will be stable at USD 33.17 billion, while Latin America’s renewables will witness a 20.1% jump in capacity and USD 17.7 billion in investment.“Worldwide, we see that as the number of countries cutting subsidies increases, the market is compelled to consider purely commercial alternatives to feed-in tariffs, such as competitive auctions and private-sector power purchase agreements,” said Maria Benintende, Energy & Environment Senior Industry Analyst.More: Renewables investment in 2018 seen at USD 228bn, slow growth due to Chinalast_img read more

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CFPB gives CUNA members HELP Act compliance answers

first_img 9SHARESShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblr Nicholas Hluchyi, senior counsel for the Consumer Financial Protection Bureau’s (CFPB) Office of Regulations, and Terry Randall, counsel for that office, briefed CUNA members Wednesday on changes brought by the implementation of the Helping Expand Lending Practices in Rural Communities (HELP) Act.That interim final rule went into effect March 31. It is a win for credit unions and their members because it makes it possible to provide additional credit to consumers in rural and underserved areas.Wednesday’s session was moderated by Andy Price, a CUNA senior director of advocacy and counsel, who lauded the regulation as an excellent example of tailoring a rule to acknowledge the credit union difference, a policy approach strongly advocated by CUNA.The CFPB staffers reminded that the rule amends parts of Regulation Z that set eligibility requirements for small creditors that operate in rural or underserved areas to originate balloon-payment qualified mortgages. The updated small creditor threshold applies to credit unions that have less than $2 billion in assets and who originate under 2,000 covered transactions. continue reading »last_img read more

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Trump to cut Fed aid for college loans, credit unions have solution

first_imgPresident Trump is planning massive cuts to programs that have helped millions of Americans get affordable college loans, and plans to eliminate a program that offers limited debt forgiveness for some people who go to work for nonprofits.However, credit unions might help ease the impact through expansion of private loan and refinance programs, a student loan CUSO official said.The Washington Post reported Thursday on Education Department documents dated May 23 — the date the White House is expected to announce its education budget.The budget proposal calls for a $9.2 billion cut to the department, or 13.6 percent of the spending level Congress approved last month for programs from kindergarten to college. That amount is net of at least $1.7 billion in increased spending for new K-12 programs to encourage school vouchers and school choice programs. continue reading » 25SHARESShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblrlast_img read more

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Online scheduling tools: 3 stories of deployment and adoption

first_img continue reading » ShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblr When COVID-19 spread across the United States in the spring of 2020, retail institutions, including credit unions, had to pivot standard operating procedures to provide member service while adhering to social distancing and other safety guidelines.Appointment scheduling is one response to COVID-19 that has gained in popularity. In normal times, it allows members to tap credit union assistance on their own schedule. In the corona times, such systems allow credit unions to control the number of people in any given branch at any given time — no small benefit in an era of contact tracing and social distancing.Here, leaders from Discovery Federal Credit Union, DuPage Credit Union, and Northwest Community Credit Union talk about the day-to-day operation of their systems. To learn about the past, present, and future benefits of appointment scheduling and more, click to read their Q&As.A Strategy To Combat COVID-19 In 5 Weeks Or LessWhen COVID-19 forced the closure of branch lobbies across the country, Discovery Federal Credit Union ($161.1M, Wyomissing, PA) was already exploring online appointment scheduling and lobby management capabilities in the hopes such a system would provide a deeper understanding of why members visit a branch as well shed light on wait times, appointment length, and more.last_img read more

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Ithaca Police search for armed robbery suspect

first_imgAuthorities said the investigation is ongoing and anyone with information is asked to contact the department. Authorities said officers arrived at the scene, and after an initial investigation, they discovered the suspect had entered the store, pointed a semi-automatic pistol at the cashier and demanded money. A news release added the suspect left northbound on Meadow Street with an undisclosed amount of cash.center_img ITHACA (WBNG) — Ithaca Police are looking for a suspect after an armed robbery at a Byrne Dairy early Saturday morning.last_img

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Rodgers: Vardy is a natural goalscorer

first_img Promoted ContentTop 10 Most Romantic Nations In The WorldTop 10 TV Characters Meant To Be Iconic6 Extreme Facts About Hurricanes20 Amazing Facts About The Daenerys Of The House Of TargaryenTop 7 Best Car Manufacturers Of All TimeWho Is The Most Powerful Woman On Earth?Who Earns More Than Ronaldo?Thailand’s 10 Most Iconic LandmarksYou’ve Only Seen Such Colorful Hairdos In A Handful Of Anime6 Natural History Museums That Are Really, Really GoodCan Playing Too Many Video Games Hurt Your Body?10 Risky Jobs Some Women Do “But he is right up there with the elite strikers in world football, how he threatens the line and his explosive speed over a short distance is absolutely phenomenal. He is very focused, he is in his early 30s now but he’s still as quick as ever. read also:Barnes, Vardy doubles put Iheanacho’s Leicester back on track “He has an appetite for the game and he’s got that old school mentality where he wants to fight, he wants to run and his whole attitude to the game has been absolutely brilliant since I came in. He’s a natural goalscorer, if you get the service to him, he will finish.” FacebookTwitterWhatsAppEmail分享 Loading… center_img Leicester City boss, Brendan Rodgers has described Jamie Vardy as a player among the elite in the game. Rodgers and Vardy Rodgers has enjoyed working with the veteran striker. He told Sky Sports: “Before I came in, I was watching him from afar and seeing him maintain that real quality that he has as a goalscorer and I was really looking forward to working with him when I arrived. I was seeing the quality in the games, but it was going to be interesting to see how he was on a day-to-day basis.Advertisementlast_img read more

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Rohan Bopanna leads support for Bhupathi amid removal reports

first_imgKolkata: Amidst reports of Mahesh Bhupathi’s contract being under threat if India fails to qualify for the Davis Cup World Group Finals, veteran Rohan Bopanna on Thursday backed his non-playing captain saying his regular communication with them makes him different from previous skippers.“A lot more communication with the players not only just during the Davis Cup tie but throughout the entire year. That makes the big difference,” Bopanna told reporters when asked how is Bhupathi different to previous captains he has played under.Bopanna was speaking on the eve of India’s World Group qualifiers tie against Italy at the Calcutta South Club here.According to reports, the All India Tennis Association (AITA) may look for a new captain if the team will remain in the Asia/Oceania Group I, as Bhupathi’s term will be over after this contest.Bhupathi had replaced Anand Amritraj as captain in April 2017. The Italy tie will be fifth under Bhupathi – the multiple Grand Slam winner – who began with a 4-1 win over Uzbekistan in Bengaluru.“Like Divij (Sharan) mentioned, even though you don’t meet him so often but the communication you constantly have brings in a bigger camaraderie when you come into the Davis Cup tie,” Bopanna, 38, said.Asked how Bhupathi motivates, Rohan continued: “From 1997, when I first met him till today, he is very much experienced and a senior player to me.“No matter which tournament I played, wherever it was, he always gave that advice which was required and for a player to grow.“I think that comes from within him as a player. I don’t think he needs to go out there to wanting to really do it. The minute he sees any one of us play and if if sees there’s something we can improve and change, it just comes naturally to him.“That’s the beauty of a player. It’s great to have him as a captain for us to get better and become better tennis players.”His doubles partner Divij Sharan had echoed Bopanna.“Obviously we don’t get to spend that much time with as we’re travelling 30-35 weeks. But he very closely follows all our matches. I always hear from him. He watches them online. It’s great to have him by our side and be there on court by our side.”The pair will take on Italy’s top-ranked players Marco Cecchinato and Simone Bolleli in the doubles rubber on Saturday.Ramkumar Ramanathan and Prajnesh Gunneswaran, the singles players for India, also heaped praise on Bhupathi under whom the team twice reached the World Group Play-off stage.“He’s an invaluable addition to the team. The fact is he’s played at a very high level for a long time and all of us are better off taking his advice. He’s definitely won many Davis Cup matches under high pressure and he knows how to help us deal with all the things that come with Davis Cup. I’m very happy that he’s here with us,” said Prajnesh, who will play the second singles tie on Friday against Italy’s debutant Mateeo Berrettini.“I mean we all have a lot of respect and that’s the very important thing out of all. Having him sitting by our side, puts any team under a lot of pressure. It’s good to have him,” said Ramkumar whose first rubber is against Italy’s highest ranked singles player Andrea Seppi.Bopanna was also asked about the new format where the ties are made to two days with two singles on Friday and a doubles plus two singles on Saturday. IANSAlso Read: Sports Newslast_img read more

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Other Sports Saina Nehwal, Kidambi Srikanth enter quarterfinal of Malaysia Masters Badminton tournament

first_imgSaina Nehwal has an 8-4 head-to-head record against OkuharaSaina could face Carolina Marin in the next roundKidambi Srikanth could face Son Wan Ho in next round Kuala Lumpur: Saina Nehwal and Kidambi Srikanth produced yet another fine display to progress to the quarterfinal of the Malaysia Masters in Kuala Lumpur on Thursday. Saina, seeded seventh, took 39 minutes to tame Hong Kong’s Pui Yin Yip 21-14 21-16 in her second round women’s singles encounter. The London Olympics bronze medallist will play second seed and 2017 world champion Nozomi Okuhara of Japan in the last-eight stage of the first Super 500 tournament of the year on Friday. World no. 9 Saina holds an 8-4 overall head-to-head record against Okuhara, which includes back-to-back wins over the current world no.2 in the last two tournaments — last year’s Demark Open and the French Open. If Saina manages to go past Okuhara, the Indian might run into fourth seed Carolina Marin, who is placed in her half of the draw.Saina got off to a solid start, taking a strong 11-3 lead against Yin at mid-break in the first game. Continuing with the momentum, Saina finished the first game 21-14. In the second game, Yin showed some resilience but still trailed 7-11. In the second half, Saina gave her Hong Kong opponent very few chances and wrapped up the game 21-16 in her favour. In men’s singles, Srikanth continued his unbeaten run with a hard-fought 23-21 8-21 21-18 win over Hong Kong’s Wong Wing Ki Vincent to set up a fight with fourth seeded Korean Son Wan Ho. The seventh seeded Indian, who had a title-less run last season, has a 4-5 head-to-head count against the Korean world no 5. Former Commonwealth Games champion Parapulli Kashyap, however, bowed out of the tournament after his fight ended with a 17-21 23-25 loss to Anthony Sinisuka Ginting of Indonesia.     Srikanth had a tough outing against Vincent with the match lasting an hour and four minutes. In the first game, Vincent and Srikanth took the game to the tie breaker. But Srikanth held his nerves, finishing the game 23-21. The second game was a one-sided affair as Vincent registered a 21-8 win in the second game taking the match into the decider. In the final game, both the players displayed superb on-court play with Srikanth taking a slender 11-8 lead at mid-break. The World No.8 then held on to his lead and eventually won the game 21-18Women’s doubles pair of Ashwini Ponnappa and N Sikki Reddy also suffered an 18-21 17-21 loss to Indonesian combination of Ni Ketut Mahadewi Istarani and Rizki Amelia Pradipta. highlights For all the Latest Sports News News, Other Sports News, Download News Nation Android and iOS Mobile Apps.last_img read more

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