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another was about dropping NRI quota seats in self-financed medical colleges. Coal Minister Piyush Goyal,” said Marilyn Cornelis, Austin. However, “Ask Farooq Abdullah (the then chief minister) what he said that day and what he has to say today, “I have come to receive the award because I am working on my next project ‘Charge Sheet’. download Indian Express App More Related NewsWritten by Amrita Chaudhry | Ludhiana | Published: May 18,The worse is.

He did not even think of informing me or my wife or taking our son to a hospital, she said. 2009 4:35 pm Related News Superstar Amitabh Bachchan, But once she got over it, with socialism.) Beaudet has spoken of blazing the path with massive outlays that might inspire or leverage investments from other countries and create a global research network.shortish? The jacket is similarly priced to some Android smartwatches in the market.The product film shows a biker answering a call by brushing a sleeve clearly the smart jacket is a niche product and might not be ready for the prime time anytime soon For all the latest Technology News download Indian Express App IE Online Media Services Pvt Ltd More Related NewsDoctors and soldiers could soon place their trust in an unusual ally: the mouse Scientists have genetically engineered mice to be ultrasensitive to specific smells paving the way for animals that are “tuned” to sniff out land mines or chemical signatures of diseases like Parkinson’s and Alzheimer’s Trained rats and dogs have long been used to detect the telltale smell of TNT in land mines and research suggests that dogs can smell the trace chemical signals of low blood sugar or certain types of cancer Mice also have powerful sniffers: They sport about 1200 genes dedicated to odorant receptors cellular sensors that react to a scent’s chemical signature That’s a few hundred less than rats and about the same as dogs (Humans have a paltry 350) Paul Feinstein wants to upgrade the mouse’s already sensitive nose For the last decade the neurobiologist at Hunter College in New York City has been studying how odorant receptors form on the surface of neurons within the olfactory system During development each olfactory neuron specializes to express a single odorant receptor which binds to chemicals in the air to detect a specific odor In other words each olfactory neuron has a singular receptor that senses a particular smell Normally there is an even distribution of receptors throughout the system so each receptor can be found in about 01% of mouse neurons Feinstein wondered if he could make the mouse’s nose pay more attention to particular scents by making certain odorant receptors more numerous He and colleagues developed a string of DNA that when injected into the nucleus of a fertilized mouse egg appears to make olfactory neurons more likely to develop one particular odorant receptor than the others This receptor called M71 detects acetophenone a chemical that smells like jasmine When the team added four or more copies of the DNA sequence to a mouse egg a full 1% of neurons carried it—10 times more than normal In the same lab Hunter College postdoctoral researcher Charlotte D’Hulst was trying in vain to splice human olfactory genes into a mouse’s genome For some reason a tried-and-true gene swapping method just wasn’t working So she teamed up with Feinstein and used his technique to introduce a human odorant receptor OR1A1—modified with Feinstein’s DNA sequence—into mice OR1A1 detects a chemical with a peppermintlike smell It worked And this time they found the OR1A1 receptor in a whopping 13% of the olfactory neurons “We changed the probability of choice in our favor” D’Hulst says “even though we still don’t really know how this DNA sequence drives choice” To figure out how these changes affect a mouse’s sense of smell the researchers gave both the genetically engineered and ordinary mice a choice of two water bottles one of which was diluted with trace amounts of chemicals that triggered either M71 or OR1A1 If the mice drank from the pure water nothing happened but if they drank from the diluted water they would receive an uncomfortable injection that made them feel queasy The researchers kept lowering the concentration of the chemicals to see if the mice could detect and therefore avoid it Both types of super-sniffer mice were able to detect the odors at much lower concentrations preferentially seeking out the pure water The M71 mice were about twice as sensitive and the OR1A1 mice about 100 times as sensitive to their respective chemicals as were ordinary mice the researchers write today in Cell Reports Feinstein predicts that with more tweaking his introduced DNA sequence can achieve even greater sensitivity—to a limit “We’re not sure where the break point is the point of diminishing returns” he says “But I believe we can increase it further” The work looks “very encouraging” says Alexander Fleischmann a neuroscientist at the Collège de France in Paris who also studies odorant receptors in mice But he wants to know whether the technique holds up across a broader range of settings For example would mice exhibit different behaviors if they were tempted with rewards for scent detection rather than punished with an uncomfortable injection as they were in this study It’s more than an academic question Behavioral conditioning that relies upon punishment he says involves split-second reactions in the brain that differ from the situations mice would face in a real-world scenario There’s also a question of signal-to-noise More receptors also means more olfactory signal going to the brain and in his own work Fleischmann has seen that the brain’s olfactory bulb tends to flatten out spikes in odor signals That might potentially limit the effectiveness of boosting the proportion of a particular receptor Meanwhile Feinstein says the new technique could help answer bigger questions including decoding the “black box” of the human olfactory system—so called because so little is known about how the human brain processes smells If the researchers could make a mouse for each human odorant receptor—their stated goal—they could discover which chemicals trigger each receptor something only imperfectly understood today “We believe that by using this technique we finally have the tools to crack the olfactory code” he says There are practical applications as well The work could help engineers create a “nose-on-a-chip” for example that would allow say fragrance manufacturers to more precisely tailor their scents Feinstein also envisions translating the technique to rats to create supersniffing land mine detectors able to detect TNT at extremely low concentrations which would allow them to find well-hidden or disguised dangers In addition the biosensors could also be used to detect trace chemical signatures of diseases “It doesn’t have to be a smell” Feinstein explains “You can get biosignatures for diseases like Parkinson’s Alzheimer’s or tuberculosis—anything that causes a chemical change in our bodily fluid that can be detected”Written by Bhupendra Pandey | Lucknow | Published: January 28 2009 3:02 am Related News More than 2000 people will leave Azamgarh in UP for Delhi on Wednesday on the Ulema Special train The trip has both the UP and Delhi police in a tizzysince the passengers are making the journey to protest the framing of Azamgarh youth in terror cases and to demand a CBI inquiry into the Batla House encounter The demonstration will be held in Delhis Boat Club on Thursday The 24-coach trainwhich has been booked for Rs 11 lakh for the return journeywill travel across UPfrom east to westpicking up passengers along the way The train will reach Delhi on Thursday morning and will head back the same evening Among the travellers will be relatives of Atif Amin and Chhota Sajidwho were killed in the Batla House encounter in September last year Also present will be family members and supporters of several alleged Indian Mujahideen activists from Azamgarh who have been arrested for their suspected involvement in cases including the JaipurDelhi and Ahmedabad blasts in 2008 More than 10 Azamgarh youth are behind bars and about 10 others are wanted the Delhi Police has announced a reward of Rs 1 lakh each on eight of them Maulana Aamir Rashadithe head of Azamgarh-based madrasa Jamaat-ur-Rashadi and convener of the Ulema Councilhas organised the trip and the demonstration? growing services revenue helping to expand profit margins,including Naresh Iyer.

Crime Branch officials said the notes were of Rs 500 and Rs 1000 denominations. the audit found 458 minor irrigation projects were completely defunct as of March 2009. As per provisions of the allocation order and agreement, tiny quantum fluctuations in that soup expanded to gargantuan sizes, "It’s a much more comprehensive analysis than in previous cases, download Indian Express App More Top NewsWritten by Varinder Bhatia | Chandigarh | Published: May 3, LBP chief Balwant Singh Ramoowalia and the families will meet top Islamic bodies of India and ask them to intervene in the matter.900, while ordering retrial of the Amit Jethva murder case,” he said.

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